Marches quantiques ouvertes

Cette thèse est consacrée à l'étude de modèles stochastiques associés aux systèmes quantiques ouverts. Plus particulièrement, nous étudions les marches quantiques ouvertes qui sont les analogues quantiques des marches aléatoires classiques. La première partie consiste en une présentation générale des marches quantiques ouvertes. Nous présentons les outils mathématiques nécessaires afin d'étudier les systèmes quantiques ouverts, puis nous exposons les modèles discrets et continus des marches quantiques ouvertes. Ces marches sont respectivement régies par des canaux quantiques et des opérateurs de Lindblad. Les trajectoires quantiques associées sont quant à elles données par des chaînes de Markov et des équations différentielles stochastiques avec sauts. La première partie s'achève avec la présentation de quelques pistes de recherche qui sont le problème de Dirichlet pour les marches quantiques ouvertes et les théorèmes asymptotiques pour les mesures quantiques non destructives. La seconde partie rassemble les articles rédigés durant cette thèse. Ces articles traîtent les sujets associés à l'irréductibilité, à la dualité récurrence-transience, au théorème central limite et au principe de grandes déviations pour les marches quantiques ouvertes à temps continu.This thesis is devoted to the study of stochastic models derived from open quantum systems. In particular, this work deals with open quantum walks that are the quantum analogues of classical random walks. The first part consists in giving a general presentation of open quantum walks. The mathematical tools necessary to study open quan- tum systems are presented, then the discrete and continuous time models of open quantum walks are exposed. These walks are respectively governed by quantum channels and Lindblad operators. The associated quantum trajectories are given by Markov chains and stochastic differential equations with jumps. The first part concludes with discussions over some of the research topics such as the Dirichlet problem for open quantum walks and the asymptotic theorems for quantum non demolition measurements. The second part collects the articles written within the framework of this thesis. These papers deal with the topics associated to the irreducibility, the recurrence-transience duality, the central limit theorem and the large deviations principle for continuous time open quantum walks

Central Limit Theorem and Large Deviation Principle for Continuous Time Open Quantum Walks

International audienceOpen Quantum Walks (OQWs), originally introduced in [2], are quantum generalizations of classical Markov chains. Recently, natural continuous time models of OQW have been developed in [24]. These models, called Continuous Time Open Quantum Walks (CTOQWs), appear as natural continuous time limits of discrete time OQWs. In particular they are quantum extensions of continuous time Markov chains. This article is devoted to the study of homogeneous CTOQW on Z^d. We focus namely on their associated quantum trajectories which allow us to prove a Central Limit Theorem for the "position" of the walker as well as a Large Deviation Principle

Open quantum walks

Cette thèse est consacrée à l'étude de modèles stochastiques associés aux systèmes quantiques ouverts. Plus particulièrement, nous étudions les marches quantiques ouvertes qui sont les analogues quantiques des marches aléatoires classiques. La première partie consiste en une présentation générale des marches quantiques ouvertes. Nous présentons les outils mathématiques nécessaires afin d'étudier les systèmes quantiques ouverts, puis nous exposons les modèles discrets et continus des marches quantiques ouvertes. Ces marches sont respectivement régies par des canaux quantiques et des opérateurs de Lindblad. Les trajectoires quantiques associées sont quant à elles données par des chaînes de Markov et des équations différentielles stochastiques avec sauts. La première partie s'achève avec la présentation de quelques pistes de recherche qui sont le problème de Dirichlet pour les marches quantiques ouvertes et les théorèmes asymptotiques pour les mesures quantiques non destructives. La seconde partie rassemble les articles rédigés durant cette thèse. Ces articles traîtent les sujets associés à l'irréductibilité, à la dualité récurrence-transience, au théorème central limite et au principe de grandes déviations pour les marches quantiques ouvertes à temps continu.This thesis is devoted to the study of stochastic models derived from open quantum systems. In particular, this work deals with open quantum walks that are the quantum analogues of classical random walks. The first part consists in giving a general presentation of open quantum walks. The mathematical tools necessary to study open quan- tum systems are presented, then the discrete and continuous time models of open quantum walks are exposed. These walks are respectively governed by quantum channels and Lindblad operators. The associated quantum trajectories are given by Markov chains and stochastic differential equations with jumps. The first part concludes with discussions over some of the research topics such as the Dirichlet problem for open quantum walks and the asymptotic theorems for quantum non demolition measurements. The second part collects the articles written within the framework of this thesis. These papers deal with the topics associated to the irreducibility, the recurrence-transience duality, the central limit theorem and the large deviations principle for continuous time open quantum walks

Ultrafast Gene Fusion Assessment for Nonsquamous NSCLC

Introduction: Gene fusion testing of ALK, ROS1, RET, NTRK, and MET exon 14 skipping mutations is guideline recommended in nonsquamous NSCLC (NS-NSCLC). Nevertheless, assessment is often hindered by the limited availability of tissue and prolonged next-generation sequencing (NGS) testing, which can protract the initiation of a targeted therapy. Therefore, the development of faster gene fusion assessment is critical for optimal clinical decision-making. Here, we compared two ultrafast gene fusion assays (UFGFAs) using NGS (Genexus, Oncomine Precision Assay, Thermo Fisher Scientific) and a multiplex reverse-transcriptase polymerase chain reaction (Idylla, GeneFusion Assay, Biocartis) approach at diagnosis in a retrospective series of 195 NS-NSCLC cases and five extrapulmonary tumors with a known NTRK fusion. Methods: A total of 195 NS-NSCLC cases (113 known gene fusions and 82 wild-type tumors) were included retrospectively. To validate the detection of a NTRK fusion, we added five NTRK-positive extrathoracic tumors. The diagnostic performance of the two UFGFAs and standard procedures was compared. Results: The accuracy was 92.3% and 93.1% for Idylla and Genexus, respectively. Both systems improved the sensitivity for detection by including a 5′-3′ imbalance analysis. Although detection of ROS1, MET exon 14 skipping, and RET was excellent with both systems, ALK fusion detection was reduced with sensitivities of 87% and 88%, respectively. Idylla had a limited sensitivity of 67% for NTRK fusions, in which only an imbalance assessment was used. Conclusions: UFGFA using NGS and reverse-transcriptase polymerase chain reaction approaches had an equal level of detection of gene fusion but with some technique-specific limitations. Nevertheless, UFGFA detection in routine clinical care is feasible with both systems allowing faster initiation of therapy and a broad degree of screening